The Effectiveness of Meloxicam Adjuvant Therapy against Negative Symptoms and Neutrophil Lymphocyte Ratio (NLR) in Schizophrenic Patients

Highlights:1. The NLR value can show the role of neuroinflammation in schizophrenic patients.2. Meloxicam as adjuvant therapy improve negative symptoms and changes patients. AbstractIntroduction: Neutrophil-lymphocyte ratio is a simple affordable marker inflammation that has recently been widely used to assess systemic psychiatric This study aimed determine analyze effectiveness meloxicam neutrophil-lymphocyte (NLR) Methods: was quasi-experimental using single-blind, pretest–post-test design. Subjects were determined purposive sampling technique based on inclusion criteria. examined 34 samples divided them into two groups. treatment group consisted 17 subjects who received with 15 mg/day for 4 weeks control group. Data collection obtained from medical records, interviews, field notes, positive scale, general psychopathology scale (PANSS) assessment sheets, blood examinations. analysis SPSS 25.0.Results: subscale PANSS score decreased lower than group, p-value = 0.640. However, decrease values more significant 0.094. There scores clinical scores, but it not statistically significant.Conclusion: Adjuvant Meloxicam, given once day four weeks, had an effect decreasing patients at Dr. Arif Zainudin Regional Mental Hospital (RSJD), Surakarta, clinically, significant.